Relationship of cellular potential hemolysin in group A streptococci to extracellular streptolysin S
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چکیده
منابع مشابه
Cellular streptolysin S-related hemolysins of group A Streptococcus C203S.
Group A streptococci strain C203S, grown in heart infusion broth with 0.3% maltose, produce two cellular hemolysins related to extracellular streptolysin S (SLS). Enzymatic lysis of the streptococci by group C streptococcal phage-associated lysin results in release of low titer, labile hemolysin, which can be stabilized by ribonucleic acid (RNA)-core (RNA preparation from yeast). This labile he...
متن کاملDecreased production of RNA-streptolysin S in streptococci devoid of extracellular RNase activity.
In cultures of certain streptococcal strains, RNA added as a carrier for streptolysin S (SLS) was hardly degraded, owing to deficiency of extracellular RNase activity. Production of RNA-SLS into culture supernatant was markedly reduced in the RNase-deficient streptococci. Even in these RNase-less strains, guanylic-acid rich oligonucleotides, polyG or trypan blue effectively induced SLS producti...
متن کاملTransduction of the genetic determinant for streptolysin S in group A streptococci.
The genetic determinant for streptolysin S production (SLS+) was successfully transduced to two naturally occurring nonhemolytic strains of group A streptococci (Streptococcus pyogenes), an M-type 18 strain associated with an outbreak of rheumatic fever and an M-negative variant of a type 49 strain isolated from a skin lesion. Attempts to transduce this determinant to a nonhemolytic M-type 68 s...
متن کاملCytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci.
Although the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purified group A streptococci (GAS) has been established, the effect of these molecules in natural infection is not well understood. To identify whether biologically relevant concentrations of SLO and SLS were cytotoxic to epithelial and phagocytic cells that the bacteria would typically encounter during human infection a...
متن کاملEnhanced production of cell-bound and extracellular streptolysin S by hemolytic streptococci pretreated with proteases.
The amount of streptolysin S produced by resting streptococci was considerably increased after incubation of the washed bacteria with trypsin or pronase. Production of both cell-bound and free forms of the toxin was enhanced by the protease treatment. By addition of trypsin, streptolysin S yield was considerably increased in growing culture as well. Treatment with lysozyme was ineffective, and ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1976
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.13.3.813-817.1976